Terrence R Burke Selected Research

Integrases

11/2021	HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants.
1/2021	Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.
1/2021	Integrase Strand Transfer Inhibitors Are Effective Anti-HIV Drugs.
1/2018	Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants.
1/2016	Selectivity for strand-transfer over 3'-processing and susceptibility to clinical resistance of HIV-1 integrase inhibitors are driven by key enzyme-DNA interactions in the active site.
1/2016	6,7-Dihydroxyisoindolin-1-one and 7,8-Dihydroxy-3,4-Dihydroisoquinolin- 1(2H)-one Based HIV-1 Integrase Inhibitors.
2/2014	Bicyclic 1-hydroxy-2-oxo-1,2-dihydropyridine-3-carboxamide-containing HIV-1 integrase inhibitors having high antiviral potency against cells harboring raltegravir-resistant integrase mutants.

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Terrence R Burke Research Topics

Disease

24	Neoplasms (Cancer) 01/2020 - 06/2003
9	Infections 12/2021 - 10/2002
8	Acquired Immunodeficiency Syndrome (AIDS) 11/2021 - 12/2002
4	Neoplasm Metastasis (Metastasis) 02/2009 - 07/2007
2	Ovarian Neoplasms (Ovarian Cancer) 01/2019 - 01/2016
2	Breast Neoplasms (Breast Cancer) 10/2018 - 10/2002
2	Plague (Bubonic Plague) 11/2003 - 08/2003
1	HIV Infections (HIV Infection) 01/2016
1	Leukemia 12/2014
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/2014
1	Carcinogenesis 02/2009
1	Starvation 10/2006
1	Hamartoma 10/2006
1	Cysts 10/2006
1	Birt-Hogg-Dube Syndrome 10/2006
1	Bone Resorption 04/2004
1	Osteoporosis 04/2004

Drug/Important Bio-Agent (IBA)

7	IntegrasesIBA 11/2021 - 02/2014
6	Human immunodeficiency virus 1 p31 integrase proteinIBA 07/2018 - 06/2009
6	Proteins (Proteins, Gene)FDA Link 01/2017 - 10/2002
4	EnzymesIBA 01/2016 - 04/2004
4	GRB2 Adaptor ProteinIBA 12/2008 - 10/2005
3	Folic Acid (Vitamin M)FDA LinkGeneric 01/2020 - 10/2012
3	Folate Receptor 1IBA 01/2019 - 08/2012
3	Protein Tyrosine PhosphatasesIBA 10/2018 - 08/2003
3	Pharmaceutical PreparationsIBA 01/2017 - 01/2006
2	SelenocysteineIBA 04/2017 - 08/2012
2	Anti-Retroviral Agents (Antiretroviral Agents)IBA 01/2016 - 02/2014
2	Peptides (Polypeptides)IBA 10/2012 - 10/2005
2	PeptidomimeticsIBA 05/2009 - 10/2006
2	Amino Acids FDA Link 05/2009 - 10/2006
2	Phosphotransferases (Kinase)IBA 02/2009 - 10/2005
2	Tyrosine (L-Tyrosine)FDA Link 02/2009 - 10/2005
1	Reverse Transcriptase InhibitorsIBA 12/2021
1	NucleosidesIBA 12/2021
1	dolutegravirIBA 12/2021
1	Carrier Proteins (Binding Protein)IBA 01/2020
1	imidazole mustard (BIC)IBA 01/2020
1	Bispecific AntibodiesIBA 01/2019
1	Class 4 Receptor-Like Protein Tyrosine PhosphatasesIBA 10/2018
1	Immunoconjugates (Immunoconjugate)IBA 04/2017
1	RA190IBA 01/2017
1	Deubiquitinating EnzymesIBA 01/2017
1	Polo-Like Kinase 1IBA 01/2017
1	PiperidonesIBA 01/2017
1	UbiquitinIBA 01/2017
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2017
1	HaptensIBA 01/2016
1	HIV Integrase InhibitorsIBA 07/2014
1	Raltegravir Potassium FDA Link 12/2012
1	elvitegravirIBA 12/2012
1	IntegrinsIBA 08/2012
1	Immunoglobulin FragmentsIBA 08/2012
1	Cyclic PeptidesIBA 05/2009
1	Proto-Oncogene Proteins c-metIBA 02/2009
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 02/2009
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2008
1	Fc Receptors (Fc Receptor)IBA 11/2008
1	Integrin alpha4beta1 (VLA-4)IBA 11/2008
1	Dicumarol (Dicoumarol)FDA Link 12/2007
1	Superoxides (Superoxide)IBA 12/2007
1	NAD (NADH)IBA 12/2007
1	quinone (benzoquinone)IBA 12/2007
1	Estrogen Receptor alphaIBA 03/2007
1	cyclopentenoneIBA 03/2007
1	PPAR gammaIBA 03/2007
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 10/2006
1	TOR Serine-Threonine KinasesIBA 10/2006
1	Sirolimus (Rapamycin)FDA Link 10/2006
1	Growth Factor ReceptorsIBA 01/2006
1	tyrosine receptor (receptor, tyrosine)IBA 10/2005
1	Phosphorus (Red Phosphorus)IBA 10/2005
1	Hormones (Hormone)IBA 07/2005
1	Biological ProductsIBA 04/2004
1	Virulence Factors (Pathogenicity Factors)IBA 08/2003
1	LigandsIBA 06/2003
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 10/2002
1	L 708906IBA 10/2002

Therapy/Procedure

12	Therapeutics 11/2019 - 06/2003
2	Immunotherapy 01/2019 - 01/2016
1	Drug Therapy (Chemotherapy) 12/2002